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Activomics

Activomics® is a different approach

to biomarker discovery

Five factors differentiate Activomics® from other biomarker discovery platforms: The focus is on activity rather than protein concentration per se. Many studies attest to the primordial importance of PTMs on the activation/deactivation of proteins in the regulation/deregulation of physiological processes. Sensitive detection of the PTM activities is based on the inherent specificity of enzyme function allowing low abundance biomarkers to be detected without requirement for the depletion highly abundant proteins (as in top down proteomics). No complicated prefractionation techniques are required, reducing time and costs in sample workup. The assays work on complex samples such as serum or unfractionated cell lysates. Adaptability for validation steps is ensured by the ease with which the activity based detection can be moved to alternative formats suited to standard clinical or diagnostic laboratory set-ups. Originality: in breaking away from conventional protein quantitative approaches there is an enormous untapped potential to find novel links between deregulated enzyme activities and disease.
© Copyright 2016 IP Research Consulting. All right reserved.
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Activomics

Activomics® is a different approach to

biomarker discovery

Five factors differentiate Activomics® from other biomarker discovery platforms: The focus is on activity rather than protein concentration per se. Many studies attest to the primordial importance of PTMs on the activation/deactivation of proteins in the regulation/deregulation of physiological processes. Sensitive detection of the PTM activities is based on the inherent specificity of enzyme function allowing low abundance biomarkers to be detected without requirement for the depletion highly abundant proteins (as in top down proteomics). No complicated prefractionation techniques are required, reducing time and costs in sample workup. The assays work on complex samples such as serum or unfractionated cell lysates. Adaptability for validation steps is ensured by the ease with which the activity based detection can be moved to alternative formats suited to standard clinical or diagnostic laboratory set-ups. Originality: in breaking away from conventional protein quantitative approaches there is an enormous untapped potential to find novel links between deregulated enzyme activities and disease.
Activomics